Oct 2006 Admitted to Henan XXX Tumour Hospital. Diagnosed with cancer of left breast. Underwent modified radical mastectomy. Dec 2006 underwent TA chemotherapy 4 cycles . April 2007 discovered tumour above left clavicle. Needle biopsy revealed metastasis in mammary gland lymph nodes. Also discovered metastasis in both lungs and mediastinum. Underwent Chemo again but was not found to be effective. Disease continued to worsen with emergence of pleural effusion. The doctors advised her to seek treatment elsewhere. June 2007 she arrived at the hospital for treatment.
Pathological diagnosis on admission to You Hao hospital: Poorly differentiated adenocarcinoma of the left breast, Partly clear cell carcinoma, partly medullary carcinoma, Vascular invasion. Immunohistochemical staining test results: ER(+), PR(+), CERBB-2 (+++), CA15-3 (++) with Metastases in both lungs, mediastinum, upper left clavicular lymph nodes, And Fluid retention in the thoracic cavity.
Treatment: Due to the fact that the disease was in a very advanced stage and chemotherapy was no longer a viable option, the specialists proposed the use of biotherapy. After one course of conventional biotherapy treatment (cord blood CIK) the patient reported less chest pain, less chest distress, and the clavicular mass showed significant reduction in size. However after half a month the supraclavicular lymph node tumours showed enlargement. The second round of biotherapy did not result in much obvious improvement. The patient displayed symptoms of taking a turn for the worse. There was increased pleural effusion, chest pain, unable to lie flat on her back during sleep, required pleural effusion drainage every 2-3 days. Increased metastatic foci in the lungs, infringement on the bronchial tubes. Severe coughing day and night, unable to sleep at night. Poor appetite, weak, did not even have the strength to get out of bed.
23 July 2007 PET/CT scan showed: 1) Recurrence and metastasis of cancer after modified radical mastectomy of left breast and chemotherapy. Had nuclear implantation done. Wide recurrence of cancer in the left chest wall. 2) Diffuse metastasis in both lungs, and both sides of the thymus with medium quantity of dropsy. 3) Multiple metastasis in lymph nodes above both clavicles, beneath left armpit, in bilateral porta pulmonis, and mediastinum. 4) Systemic multiple metastases in bones.
Clinical symptoms and examinations indicated that the disease was at a very advanced stage. The doctors felt that at any time there was mortal danger to the patient. They did not have any options except to advise the patient to return home to Anyang as soon as possible.
Miraculous turnaround From Guangzhou to Anyang by train is a 20 odd hour journey. For the safety of the patient, the doctors planned to drain out the fluid from the chest before discharge from the hospital and considered to do biotherapy one more time to improve the condition of the patient for her safe return to her hometown. Upon admission to the hospital it was discovered upon examination that the patient’s immunocyte count was 1195/µl and that of her husband’s was 3242/µl which was almost 3 times as much. The doctors decided to try out a new method of preparing the biotherapy medicine – that of using the husband’s immunocytes for the preparation of the CIK treatment for the patient. Till then this method was yet unreported anywhere within China and abroad. It was a bold attempt and resulted in a miracle. 26 July 2007 For the first time for the patient and very possibly in the medical history of China, healthy adult blood was used in the preparation of CIK and was administered. 27 July 2007 morning 8am during ward visit: The patient showed marked improvement in alertness and energy levels, reported less coughing during the night – only 3 times and had improved sleep during the night before. 29 July 2007 conclusion of biotherapy treatment. The response of the patient was extremely positive. The coughing had almost disappeared. Patient was able to sleep well. Appetite singnificantly improved. First time in a month that patient was able to get out of bed to tidy the room and to cook a meal. The medical doctor in charge remarked that of all the cases receiving CIK biotherapy treatment that this was the best they had seen. Under the positive influence of the biotherapy treatment the patient arrived home in Anyang safely. Because we were not familiar with the results of using healthy adult blood for CIK treatment and the patient had seemed to be on the verge of death, we had asked the family to be mentally prepared for the worst. Under normal circumstances, the survival period would not be more than 3 months. After returning home to Anyang the patient had her funeral arrangements made. Relatives came to visit to bid farewell. As our hospital did not hold out any hope for her, in the ensuing 3 months we did not follow up with her.
Unexpected good news emerged. On 19 September 2007 Professor Dr. Qi suddenly received a call from the patient saying she had recovered and had left the hospital. He could not believe his ears. On further questioning she revealed that in July upon returning home she had checked into the local hospital. In July, August September, the monthly CT scans had showed increasing improvement in her condition. The metastatic foci in the lungs and pleura had all disappeared. The metastases in the mediastinum had decreased in size significantly. 6 October 2007 CT scans reveal absence of metastatic foci in the chest, metastases in the mediastinum had completely disappeared. The patient was mentally and physically very well. 2 November 2007 Came to Guangzhou for a PET/CT scan re- examination: Metastasis after surgery and chemotherapy. After subsequent comprehensive treatment: (1) most of the tumours in the left chest wall have disappeared, metabolism reduced significantly indicating significant therapeutic effectiveness. (2) the original pervasive metastasis in both lungs have basically disappeared, the original pleural effusion in both lung has been completely absorbed. (3) The original multiple metastases in the lymph nodes above the clavicles, underneath the left armpit, in both porta pulmonis and mediastinum have largely disappeared. (4) Multiple metastasis in T 10, 11, 12, 14 and right iliac bone.
The patient when we last contacted her is back at work.
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